1.Peplau LA, Perlman D. Perspectives on loneliness. In: Peplau LA, Perlman D, editors. Loneliness: A source-book of current theory, research and therapy. New York (US): Wiley; 1982. p. 1-8.

2.Rokach A, Bacanli H, Ramberan G. Coping with Loneliness. Eur Psychol. 2000;5(4):302-11.

3.Fokkema T, De Jong Gierveld J, Dykstra PA. Cross-national differences in older adult loneliness. J Psychol Interdiscip Appl. 2012;146(1-2):201-28. doi: 10.1080/00223980.2011.631612

4.Wagner GS, McClintock SM, Rosenquist PB, McCall WV. Major Depressive Disorder with Psychotic Features May Lead to Misdiagnosis of Dementia: A Case Report and Review of the Literature. J Psychiatr Pr. 2011;17(6):432-8. doi: 10.1097/01.pra.0000407968.57475.ab

5.Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113): 2673-734. doi: 10.1016/S0140-6736(17)31363-6

6.Cacioppo JT, Hawkley LC, Thisted RA. Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology. Psychol Aging. 2010;25(2):453-63. doi: 10.1037/a0017216

7.Boss L, Kang DH, Branson S. Loneliness and cognitive function in the older adult: A systematic review. Int Psychogeriatrics. 2015;27(4):541-53. doi: 10.1017/S1041610214002749

8.Ong AD, Uchino BN, Wethington E. Loneliness and Health in Older Adults: A Mini-Review and Synthesis. Gerontology. 2016;62:443-9. doi: 10.1159/000441651

9.Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D. Loneliness and Social Isolation as Risk Factors for Mortality: A Meta-Analytic Review. Perspect Psychol Sci. 2015;10(2):227-37. doi: 10.1177/1745691614568352

10.Mihalopoulos C, Le LKD, Chatterton M Lou, Bucholc J, Holt-Lunstad J, Lim MH, et al. The economic costs of loneliness: a review of cost-of-illness and economic evaluation studies. Soc Psychiatry Psychiatr Epidemiol. 2019. doi: 10.1007/s00127-019-01733-7

11.Au R. Aging Well: Using Precision to Drive Down Costs and Increase Health Quality. Adv Geriatr Med Res. 2019;1:e190003. doi: 10.20900/agmr20190003

12.Beller J, Wagner A. Loneliness, social isolation, their synergistic interaction, and mortality. Heal Psychol. 2018;37(9):808-13. doi: 10.1037/hea0000605

13.Holwerda TJ, Deeg DJH, Beekman ATF, Van Tilburg TG, Stek ML, Jonker C, et al. Feelings of loneliness, but not social isolation, predict dementia onset: Results from the Amsterdam Study of the Elderly (AMSTEL). J Neurol Neurosurg Psychiatry. 2014;85(2):135-42. doi: 10.1136/jnnp-2012-302755

14.Mann F, Bone JK, Lloyd-Evans B, Frerichs J, Pinfold V, Ma R, et al. A life less lonely: the state of the art in interventions to reduce loneliness in people with mental health problems. Soc Psychiatry Psychiatr Epidemiol. 2017;52(6):627-38. doi: 10.1007/s00127-017-1392-y

15.Quan NG, Lohman MC, Resciniti NV, Friedman DB. A systematic review of interventions for loneliness among older adults living in long-term care facilities. Aging Ment Health. 2019;1-11. doi: 10.1080/13607863.2019.1673311

16.Coll-Planas L, Nyqvist F, Puig T, Urrútia G, Solà I, Monteserín R. Social capital interventions targeting older people and their impact on health: A systematic review. J Epidemiol Community Health. 2017;71(7):663-72. doi: 10.1136/jech-2016-208131

17.O’Rourke HM, Collins L, Sidani S. Interventions to address social connectedness and loneliness for older adults: A scoping review. BMC Geriatr. 2018;18(1):1-13. doi: 10.1186/s12877-018-0897-x

18.Gardiner C, Geldenhuys G, Gott M. Interventions to reduce social isolation and loneliness among older people: an integrative review. Heal Soc Care Community. 2018;26(2):147-57. doi: 10.1111/hsc.12367

19.Seepersad S. Helping the “Poor Get Richer”—Successful Internet Loneliness Intervention Programs. In: Sha’ked A, Rokach A, editors. Addressing Loneliness: Coping, Prevention and Clinical Interventions. Routledge (UK): Taylor & Francis; 2015. p. 231-40.

20.Newall NEG, Chipperfield JG, Bailis DS. Predicting stability and change in loneliness in later life. J Soc Pers Relat. 2014;31(3):335-51. doi: 10.1177/0265407513494951

21.Poscia A, Stojanovic J, La Milia DI, Duplaga M, Grysztar M, Moscato U, et al. Interventions targeting loneliness and social isolation among the older people: An update systematic review. Exp Gerontol. 2018;102:133-44. doi: 10.1016/j.exger.2017.11.017

22.Masi CM, Chen HY, Hawkley LC, Cacioppo JT. A Meta-Analysis of Interventions to Reduce Loneliness. Pers Soc Psychol Rev. 2011;15(3). doi: 10.1177/1088868310377394

23.Jacobson NS, Roberts LJ, Berns SB, McGlinchey JB. Methods for defining and determining the clinical significance of treatment effects: description, application, and alternatives. J Consult Clin Psychol. 1999;67(3):300-7. doi: 10.1037//0022-006x.67.3.300

24.Cacioppo JT, Hawkley LC, Crawford LE, Ernst JM, Burleson MH, Kowalewski RB, et al. Loneliness and health: Potential mechanisms. Psychosom Med. 2002;64(3):407-17. doi: 10.1097/00006842-200205000-00005

25.Cacioppo JT, Cacioppo S, Cole SW, Capitanio JP, Goossens L, Boomsma DI, et al. Loneliness Across Phylogeny and a Call for Comparative Studies and Animal Models HHS Public Access Author manuscript. Perspect Psychol Sci. 2015;10(2):202-12. doi: 10.1177/1745691614564876

26.Düzel S, Drewelies J, Gerstorf D, Demuth I, Steinhagen-Thiessen E, Lindenberger U, et al. Structural Brain Correlates of Loneliness among Older Adults. Sci Rep. 2019;9(1):1-11. doi: 10.1038/s41598-019-49888-2

27.Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, et al. Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016;73(12):1230-7. doi: 10.1001/jamapsychiatry.2016.2657

28.Hsiao YH, Chang CH, Gean PW. Impact of social relationships on Alzheimer’s memory impairment: Mechanistic studies. J Biomed Sci. 2018;25(1):1-8. doi: 10.1186/s12929-018-0404-x

29.Hyland P, Shevlin M, Cloitre M, Karatzias T, Vallières F, McGinty G, et al. Quality not quantity: loneliness subtypes, psychological trauma, and mental health in the US adult population. Soc Psychiatry Psychiatr Epidemiol. 2019;54(9):1089-99. doi: 10.1007/s00127-018-1597-8

30.Holmén K, Furukawa H. Loneliness, health and social network among elderly people—A follow-up study. Arch Gerontol Geriatr. 2002;35(3):261-74. doi: 10.1016/S0167-4943(02)00049-3

31.Victor CR. Loneliness and Later Life—Concepts, Prevalence, and Consequences. In: Sha’ked A, 31.Rokach A, editors. Addressing Loneliness: Coping, Prevention and Clinical Interventions. Routledge (UK): Taylor & Francis; 2015. p. 185-204.

32.Lopez RP, Rose KM, Kenney L, Sanborn V, Davis JD. Managing Shame: A Grounded Theory of How Stigma Manifests in Families Living With Dementia. J Am Psychiatr Nurses Assoc. 2019;26(2):181-8. doi: 10.1177/1078390319832965

33.Cohen-Mansfield J, Perach R. Interventions for alleviating loneliness among older persons: A critical review. Am J Heal Promot. 2015;29(3):e109-25. doi: 10.4278/ajhp.130418-LIT-182

34.Cacioppo S, Grippo A, London S, Goossens L, Cacioppo J. Loneliness: Clinical Import and Interventions. Perspect Psychol Sci. 2015;10(2):238-49. doi: 10.1177/1745691615570616

35.Hawkley LC, Browne MW, Cacioppo JT. How can I connect with thee? Let me count the ways. Psychol Sci. 2005;16(10):798-804. doi: 10.1111/j.1467-9280.2005.01617.x

36.Weeks MS, Asher SR. Loneliness in childhood: Toward the next generation of assessment and research. Adva Child Dev Behav. 2012;42:1-39. doi: 10.1016/B978-0-12-394388-0.00001-0

37.Ceci C, Brown HS, Judge H. Rethinking the assumptions of intervention research concerned with care at home for people with dementia. Dementia. 2018:1-17. doi: 10.1177/1471301218790037

38.Weiss, RS. Loneliness: the experience of emotional and social isolation. Cambridge (US): The MIT Press; 1973.

39.Shaver P, Burhmester D. Loneliness, sex-role orientation, and group life: A social needs perspective. In: Paulus PB, editor. Basic group processes. New York (US): Springer; 1983. p. 259-88.

40.Qualter P, Vanhalst J, Harris R, Roekel V, Lodder G, Bangee M, et al. Loneliness Across the Life Span. Perspect Psychol Sci. 2015;10(2):250-64. doi: 10.1177/1745691615568999

41.Cattan M, White M, Bond J, Learmouth A. Preventing social isolation and loneliness among older people: A systematic review of health promotion interventions. Ageing Soc. 2005;25(1):41-67. doi: 10.1017/S0144686X04002594

42.DiTommaso E, Fizell S, Robinson B. Chronic Loneliness Whitin an Attachment Framework. In: Sha’ked A, Rokach A, editors. Addressing Loneliness: Coping, Prevention and Clinical Interventions. Routledge (UK): Taylor & Francis; 2015. p. 241-54.

43.Khosravi P, Rezvani A, Wiewiora A. The impact of technology on older adults’ social isolation. Comput Human Behav. 2016;63:594-603. doi: 10.1016/j.chb.2016.05.092

44.Saito T, Kai I, Takizawa A. Effects of a program to prevent social isolation on loneliness, depression, and subjective well-being of older adults: A randomized trial among older migrants in Japan. Arch Gerontol Geriatr. 2012;55(3):539-47. doi: 10.1016/j.archger.2012.04.002

45.Hounslow Wellbeing Network, 2017. Available from: http://www.wellbeing-network.org/. Accessed 2020 Feb 28.

46.World Health Organization. ICOPE Handbook: Guidance on person-centred assessment and pathways in primary care. Geneva (Switzerland): World Health Organization; 2019.

47.Lindsay EK, Young S, Brown KW, Smyth JM, David Creswell J. Mindfulness training reduces loneliness and increases social contact in a randomized controlled trial. Proc Natl Acad Sci U S A. 2019;116(9):3488-93. doi: 10.1073/pnas.1813588116

48.Neves B, Franz R, Judges R, Beermann C, Baecker R. Can Digital Technology Enhance Social Connectedness among Older Adults? A Feasibility Study. J Appl Gerontol. 2019;38(1):49-72. doi: 10.1177/0733464817741369

49.Contrera KJ, Sung YK, Betz J, Li L, Lin FR. Change in loneliness after intervention with cochlear implants or hearing aids. Laryngoscope. 2017;127(8):1885-9. doi: 10.1002/lary.26424

50.Van Natta M, Burke NJ, Yen IH, Fleming MD, Hanssmann CL, Rasidjan MP, et al. Stratified citizenship, stratified health: Examining latinx legal status in the U.S. healthcare safety net. Soc Sci Med. 2019;220:49-55. doi: 10.1016/j.socscimed.2018.10.024

51.Rokach A. Effective Coping with Loneliness: A Review. Open J Depress. 2018;7:89011. doi: 10.4236/ojd.2018.74005

52.Schoenmakers EC, van Tilburg TG, Fokkema T. Coping with loneliness: What do older adults suggest? Aging Ment Heal. 2012;16(3):353-60. doi: 10.1080/13607863.2011.630373

53.Bondi M, Edmonds EC, Jak AJ, Clark LR, Delano-Wood L, McDonald CR, et al. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimerʼs Dis. 2014;42(1):275-89. doi: 10.3233/JAD-140276.Neuropsychological

54.Perna G, Grassi M, Caldirola D, Nemeroff CB. The revolution of personalized psychiatry: Will technology make it happen sooner? Psychol Med. 2018;48(5):705-13. doi: 10.1017/S0033291717002859

55.Dahlberg L, Mckee KJ. Correlates of social and emotional loneliness in older people: Evidence from an English community study. Aging Ment Heal. 2014;18(4):504-14. doi: 10.1080/13607863.2013.856863

56.Campaign to end loneliness. Available from: https://www.campaigntoendloneliness.org. Accessed 2020 Feb 28.

57.Children and Social Work Act 2017. Available from: http://www.legislation.gov.uk/ukpga/2017/16/notes/division/3/index.htm. Accessed 2020 Feb 28.

58.De Vlaming R, Haveman-Nies A, Van’t Veer P, De Groot LC. Evaluation design for a complex intervention program targeting loneliness in non-institutionalized elderly Dutch people. BMC Public Health. 2010;10:552. doi: 10.1186/1471-2458-10-552

59.Gómez-Carrillo A, Langlois-Thérien T, Kirmayer LJ. Precision Psychiatry—Yes, but Precisely What? JAMA Psychiatry. 2018;75(12):1302-03. doi: 10.1001/jamapsychiatry.2018.2651

60.Akhter-Khan SA, Wai KM. Can COVID-19 move Myanmar in the right direction? Perspectives on older people, mental health, and local organizations. Am J Geriatr Psychiatry. 2020. doi: 10.1016/j.jagp.2020.06.004

61.Schüssler-Fiorenza Rose SM, Contrepois K, Moneghetti KJ, Zhou W, Mishra T, Mataraso S, et al. A longitudinal big data approach for precision health. Nat Med. 2019;25(5):792-804. doi: 10.1038/s41591-019-0414-6

62.Bouwman TE, Aartsen MJ, van Tilburg TG, Stevens NL. Does stimulating various coping strategies alleviate loneliness? Results from an online friendship enrichment program. J Soc Pers Relat. 2017;34(6):793-811. doi: 10.1177/0265407516659158

63.Pauly T, Lay JC, Kozik P, Graf P, Mahmood A, Hoppmann CA. Technology, physical activity, loneliness, and cognitive functioning in old age. GeroPsych J Gerontopsychol Geriatr Psychiatry. 2019;32(3):111-23. doi: 10.1024/1662-9647/a000208

64.Jarvis MA, Padmanabhanunni A, Chipps J. An evaluation of a low-intensity cognitive behavioral therapy mHealth-supported intervention to reduce loneliness in older people. Int J Environ Res Public Health. 2019;16(7):1305. doi: 10.3390/ijerph16071305

65.Bertel D, Teles S, Strohmeier F, Vieira-Marques P, Schmitter P, Ruscher SH, et al. High tech, high touch: Integrating digital and human AAL advisory services for older adults. In: Bamidis PD, Ziefle M, Maciaszek L, editors. In: Proceedings 4th International Conference Information Communication Technology Ageing Well e-Health; 2018 Mar 22-23; Funchal, Madeira, Portugal. Setúbal (Portugal): Scitepress; 2018. p. 241-9. doi: 10.5220/0006799002410249

66.Cotten SR, Anderson WA, McCullough BM. Impact of internet use on loneliness and contact with others among older adults: Cross-sectional analysis. J Med Internet Res. 2013;15(2):e39. doi: 10.2196/jmir.2306

67.Baker S, Warburton J, Waycott J, Batchelor F, Hoang T, Dow B, et al. Combatting social isolation and increasing social participation of older adults through the use of technology: A systematic review of existing evidence. Australas J Ageing. 2018;37(3):184-93. doi: 10.1111/ajag.12572

68.Baecker R, Sellen K, Crosskey S, Boscart V, Neves BB. Technology to reduce social isolation and loneliness. In: Kurniawan S, Richards J, editors. Proceedings of 16th Int ACM SIGACCESS Conf Comput Access (ASSETS14); 2014 Oct 20-22; Rochester, New York, USA. New York (US): Association for Computing Machinery; 2014. p. 27-34. doi: 10.1145/2661334.2661375

69.Lim MH, Rodebaugh TL, Eres R, Long KM, Penn DL, Gleeson JFM. A Pilot Digital Intervention Targeting Loneliness in Youth Mental Health. Front Psychiatry. 2019;10:1-13. doi: 10.3389/fpsyt.2019.00604

70.Sano A, Taylor S, McHill AW, Phillips AJ, Barger LK, Klerman EPR. Identifying Objective Physiological Markers and Modifiable Behaviors for Self-Reported Stress and Mental Health Status Using Wearable Sensors and Mobile Phones: Observational Study. J Med Internet Res. 2018;20(6):e210. doi: 10.2196/jmir.9410

71.Chow PI, Fua K, Huang Y, Bonelli W, Xiong H, Barnes LE, et al. Using mobile sensing to test clinical models of depression, social anxiety, state affect, and social isolation among college students. J Med Internet Res. 2017;19(3):1-12. doi: 10.2196/jmir.6820

72.Palmius N, Tsanas A, Saunders KEA, Bilderbeck AC, Geddes JR, Goodwin GM, De Vos M. Detecting Bipolar Depression from Geographic Location Data. IEEE Trans Biomed Eng. 2019;64:1761-71. doi: 10.1109/TBME.2016.2611862

73.Van Til K, McInnis MG, Cochran A. A comparative study of engagement in mobile and wearable health monitoring for bipolar disorder. Bipolar Disord. 2019;22(2):182-90. doi: 10.1111/bdi.12849

74.Doryab A, Villalba DK, Chikersal P, Dutcher JM, Tumminia M, Liu X, et al. Identifying behavioral phenotypes of loneliness and social isolation with passive sensing: Statistical analysis, data mining and machine learning of smartphone and fitbit data. JMIR mHealth uHealth. 2019;7(7):e13209. doi: 10.2196/13209

75.Gideon J, Matton K, Anderau S, McInnis MG, Provost EM. When to Intervene: Detecting Abnormal Mood using Everyday Smartphone Conversations. arXiv:1909.11248v2
[Preprint] 2019 Sep 10. Available from: https://arxiv.org/abs/1909.11248. Accessed 2020 Jun 17.

76.Tuarob S, Tucker CS, Kumara S, Giles CL, Pincus AL, Conroy DE, et al. How are you feeling?: A personalized methodology for predicting mental states from temporally observable physical and behavioral information. J Biomed Inform. 2017;68:1-19. doi: 10.1016/j.jbi.2017.02.010